Tretiva (tretinoin): What it does and how to use it

Tretiva is a tretinoin cream used for acne and to smooth fine lines. It speeds up skin cell turnover, helps clear clogged pores, and can improve texture over time. Many people see visible changes in 8–12 weeks, but skin often looks worse before it gets better. If you want faster results, understand that patience and the right routine matter more than using more product.

How to use Tretiva safely

Apply a pea-sized amount to clean, dry skin at night. Dab small dots across your face and gently spread—don’t rub hard. Start every third night for the first 2–4 weeks, then increase to every other night, and finally nightly if your skin tolerates it. Use a gentle cleanser and avoid abrasive scrubs while your skin adapts.

Always apply moisturizer after tretinoin if your skin feels dry. Some people prefer the “sandwich” method: moisturizer, tretinoin, then a light layer of moisturizer again to reduce irritation. Avoid using benzoyl peroxide at the same time; alternate them (one at night, the other in the morning) or check with your prescriber because combining can inactivate tretinoin.

Common side effects and simple fixes

Expect redness, peeling, dryness, and mild stinging early on. These are normal signs your skin is adjusting. If irritation is severe, cut back frequency, use a thicker moisturizer, or take a short break. If you develop swelling, severe blistering, or signs of infection, stop treatment and contact your healthcare provider.

Tretinoin makes skin much more sensitive to sun. Use a broad-spectrum SPF 30+ every morning and wear a hat when you’re outside. Even short walks can add up to extra UV exposure, so protect your skin daily.

Pregnant or breastfeeding? Topical retinoids are generally not recommended in pregnancy. Tell your doctor if you’re pregnant, planning pregnancy, or breastfeeding before starting tretinoin.

If you’re new to tretinoin, set expectations: it won’t clear everything overnight. Acne that’s deep or cystic may need antibiotics, hormonal treatments, or other prescription meds. If you don’t see improvement after 3 months or your acne worsens, talk to your dermatologist about alternatives or adding treatments.

Storage is simple: keep the tube in a cool, dry place and avoid extreme heat. Don’t mix leftover products in the same container and check expiry dates—retinoids can lose strength over time.

Want to compare options? Our site covers other acne choices, from topical benzoyl peroxide and azelaic acid to prescription oral meds and newer procedures. If you have sensitive skin, your provider can help pick a lower-strength tretinoin or a different retinoid that fits your routine.

Questions about interactions with other meds, how tretinoin fits into a full skincare plan, or whether to combine with professional treatments? Ask a dermatologist. A quick consult will save time and keep your skin on track.